Progesterone Cream

Hello Formula Peeps!

Any tips on formulating with progesterone?  e.g. Interactions, pH considerations, solubilizers, etc....

I have all the safety stuff and experience to handle this chemical (professional lab, fume hood, respirator, sleeve gloves).  Not a kitchen cook fyi.

Also I'd gladly pay someone for a 30 min discussion about this too.  Just DM me.  

Thank you! 

Comments

  • PharmaPharma Member, Pharmacist
    Some thoughts:
    - Given your nickname I assume you're female. Else, it is recommended not to handle female hormones (at least not on a regular basis), even with your safety equipment.
    - Progesterone is considered a prescription drug in many countries.
    - It isn't that pH sensitive, best to keep it below pH 7.
    - Interactions: Could you be more precise? Chemically, it's quite stable, if that's what you're asking. Just to be on the safe side, don't combine with good nucleophiles such as free thiols.
    - It's best soluble in medium polarity solvents such as alcohols (progestogel, a pharmaceutical product, is a hyroalcoholic gel). What you could or have to use depends on the final concentration and where that cream will be applied.
    - You could also go for a suspension instead of a solution: jojoba oil is used in magistral preparations to obtain a 10% stock suspension which can then be integrated into oilier creams.
    - Other preparations such as vaginal suppositories (suspensions, not solutions) are based on macrogols.

    May I ask what you're planning? What you're planning doesn't sound like cosmetics...
  • @Pharma

    Thank you for the thoughts on this.  For interactions you answered what I was looking for.  My plan is to make a cream with about 10%-15% Progesterone.  This will not be labeled with any claims or intended use/dosage.  Can't find much on the web beyond basic compounding formulas using stock base from PCCA.  
  • PhilGeisPhilGeis Member, Professional formulator
    Great comments from pharma.   

    chickenskin said:
    @Pharma

    Thank you for the thoughts on this.  For interactions you answered what I was looking for.  My plan is to make a cream with about 10%-15% Progesterone.  This will not be labeled with any claims or intended use/dosage.  Can't find much on the web beyond basic compounding formulas using stock base from PCCA.  
    No claims?  Why are you using the stuff?  
  • @PhilGeis

    Personal project no intention on developing beyond personal use.
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