I made gel for methyl ester in 40% ethanol using carbomer 940, ph 7.2
After 1 month the gel turn liquid.
No significant ph change observed.
What could be the reson and solution.
Buffer?
Also i tried to change the gelling agebt and used hpmc but i gives dryout layer.
Any suggestions for the carbomer.
And if i want to change the geeling agent, any suggestions
Thanks
Comments
I am referring to conventional methyl ester.
I used cellulose ether based gelling agent but i give bad after application effect.
I don't have many gelling agents choices.
So i am looking to solve the problem if possible.
What i am thinking about is:
Use buffer ph 6_7(unfortunately carbomer 940 electrolytes senstive)
Looking for suggestions
AND YOU WILL BE SATISFIED
Will try as soon as get it
How are you neutralising the carbomer? It should be controllable to around pH 6-7 fairly easily with TEA at 40% ethanol.
I agree that it is electrolytes sensitive, which is not ideal, but it is manageable.