I have a loved one that suffers from occasional bouts of neuralgia. I would like to create a cream for pain relief (not for sale....just for personal use). I know how to make cream. I just wanted some ideas for the actives. I know the industry is full of hype / claim ingredients, so looking to narrow some of those down, and focus on the possible functional ones.
I will list some of the actives I have stumbled across, and you can comment on those, and add any you think have value. Needs to be items I can easily acquire, not prescription.
List of candidates:
Blue Tansy / Moroccan Chamomile EO (high in Chamazolene)
α-Bisabolol
Helichrysum Essential Oil
Ravensara Essential Oil
Peppermint EO
Tamanu Oil
Magnesium (what form?)
CBD products...(what form?)
And anything else that might have some evidence that it helps with nerve pain. Not saying that the above list has scientific backing.
Comments
Is capsaicin acquirable? But maybe buying 3% Lidocaine cream is easier?
If you want to play with CBD
Recommended Dose - THC:CBD (1:1) 15 – 60 mg/d
For Neuropathic pain (any causes including post-operative pain, cancer pain, non-cancer pain, neuropathic pain, Multiple sclerosis)
https://pubmed.ncbi.nlm.nih.gov/28806817/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2430692/
And lots of clinical trials in https://www.clinicaltrials.gov/
And salicylates for superficial pain.
IMHO cosmetics actives would not work or you might try looking into traditional Chinese medicine regiment you may find an acquirable ingredient.
Best of luck.
What would the inclusion rate be for a cream?
What form can I readily find salicylates in? (From cosmetic re-packers?) The willow bark extracts?
Thank you... I will look into them.
There's still no topical recommendation issued yet, the mechanism involved central nervous system so CBD cream would unlikely works. But who knows it might works for some.
Methyl salicylate, don't know it is available in cosmetic re-packers?
Since Oregon decriminalizes small amounts of Heroin and Cocaine, you might look into it as well, but be veryyyyyyyyy careful.
Regarding Methyl Salicylate..... Isn't that pretty much what Wintergreen EO is?
I am looking at Paeonol from Chinese medicine.
I am a FIRM believer in the placebo effect, so some of these ingredients will be included to 'convince' people it works.
Mission accomplished.
pretty much yes
https://go.drugbank.com/drugs/DB09543
https://patents.google.com/patent/US8889659B2/en
For some idea if you want to combine stuffs or you can look up pain relief cream from India, lots of interesting herbal stuffs.
cool, interesting never heard of topical use before.
cool, some people convince other what works or not, some people convince themselves what works or not.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5094513/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3500919/
K5 nerve pain formula:
Active: 0.25% zinc acetate Inactive: Water, Glycerin, Cetearyl Alcohol (and) Ceteareth-20, Mineral Oil, Palmitoyl Ethanolamide, Caprylhydroxamic Acid (and) Phenoxyethanol (and) Methylpropanediol, Sodium Hyaluronate, Polypodium Leucotomos, L-Citruline, Niacinamide, Philloquinone, Menaquinone, Ascorbyl Glucoside, Thioctic Acid, Cetylhydroxyproline Palmitamide, Caffeine USP, Tocopheryl Acetate, Retinyl Palmitate, Glycine Soya (soybean) seed Extract, Collagen Amino Acids, Dextrose, Calcium Carbonate, Cholecalciferol, Anandamide, Pyridoxine Hydrochloride, Buterospermum Parkii, Saccharomyces Zinc Ferment, Saccharomyces Magnesium Ferment, Saccharomyces Selenium Ferment, Water (and) Saccharomyces Zinc Ferment (and) Saccharomyces Copper Ferment (and) Saccharomyces Magnesium Ferment (and) Saccharomyces Iron Ferment (and) Saccharomyces Silicon Ferment, Panthenol, Dimethicone, Petrolatum, DI-C12-15-Alkyl Fumarate, Glycogen, Carbomer, Triisopropanolamine, Fragrance
If so...I can tweak the one I have...as it is not very bullet proof. I can add some 165 in there....since this one won't be about the 'amazing tactile' experience... Probably going to be an ugly brown color anyway.
I am already imagining a cream so ugly that only a mother could love it. Might even use the word 'salve' instead of cream.
I meant in cosmetics/supplementary diet when some people put a new strange extract in their product and make a semi-drug or drug claim, then do a hard marketing to convince their customers that it works. It makes me sad esply in cancer an CBD cycle.
I have no experience with CBD yet, I still have no access to reputable supplier other than uni lab which the price is still a bit too high.
CBD suppliers who seem to have decent paperwork
https://www.klersun.com/
https://americanhempdistributor.com/
for CBG Amyris just came out with a version dervied from sugarcane so les legal issues.