Advice for working with Resveratrol?

suswang8suswang8 Member
edited October 2020 in Advanced Questions
Hi, all.
I have seen some conflicting information online about how best to work with resveratrol as part of an emulsion and wanted your advice, please.
-1-  I believe some comments on here indicated that it should be added into the oil phase.  Is that correct?  If so, it would be solubilized into what exactly?  (I'm asking because I believe resveratrol is not oil-soluble.)
-2-  I have seen elsewhere online that a better option might be to disperse it into glycerin (?) and then add this into the cool-down phase, perhaps because of heat sensitivity?
Thank you.
(Note:  I attempted to add this question into one of the older discussions about resveratrol, but was unable to do so.)

Comments

  • PerryPerry Administrator, Professional Chemist
    It is not soluble in water. The best solvent for it is PEG400.  See this paper.
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4427559/

    I don't think the glycerin technique will help but I haven't tried it. 

    Resveratrol has a melting point ~260C, it is not heat sensitive.

  • BelassiBelassi Member, PCF student
    Advice? Sure. Don't waste your time.
    Cosmetic Brand Creation. Concept to name to IMPI search to logo and brand registration. In-house graphic design inc. Pantone specs. Cosmetic label and box design & graphics.
  • Not commenting on its skin benefits because papers I saw weren’t persuasive, but I managed to dissolve 4% in plain propylene glycol. It took an hour of stirring using a magnetic stirrer. Didn’t even had to heat it.
  • Not commenting on its skin benefits too.

    There's SalSphere® Resveratrol - encapsulated version. disperse in cool-down phase.
  • Not commenting on its skin benefits because papers I saw weren’t persuasive, but I managed to dissolve 4% in plain propylene glycol. It took an hour of stirring using a magnetic stirrer. Didn’t even had to heat it.
    Can you pls share your experience wnen used in an emulsion after dissolving it in propylene glycol -Does it get oxidized or changes color of emulsion? 
  • Resveratrol is an antioxidant and is prone to oxidation. It can change colour of the product when it oxidises itself. I noticed it in one of the products I made a while but I can’t tell when it happened. The moisturizer was over a year and the resveratrol powder I used in it also changed its colour. Ubiquinone is the same btw.
  • Belassi said:
    Advice? Sure. Don't waste your time.
    Agreed.

    or if it's intended for personal use, a suspension in hydrogel is easier to manage, shelf-life should be around 6 mo in fridge.
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