Using squalene in place of squalane

Will there be stability problems if I use squalene in place of squalane in my o/w gel cream? The % of squalene used will be just 3%-5%. If I add bht to this squalene will it prevent squalene from oxidising?
Thank you. 

Comments

  • PharmaPharma Member, Pharmacist
    Your line of thoughts is spot on, susceptibility to oxidation is the main issue. Whether or not the added amount of BHT will suffice, only trial and error will tell.
    From a theoretical physical point of view (emulsion stability), squalene in a o/w emulsion might be superior to squalane in some regards but may have a negative impact due to a lower melting point of the oil phase and therefore easier droplet fusion.
  • Pharma said:
    Your line of thoughts is spot on, susceptibility to oxidation is the main issue. Whether or not the added amount of BHT will suffice, only trial and error will tell.
    From a theoretical physical point of view (emulsion stability), squalene in a o/w emulsion might be superior to squalane in some regards but may have a negative impact due to a lower melting point of the oil phase and therefore easier droplet fusion.
    Just came across a paper on the o/w squalene emulsion.. Here's an excerpt
    "an unbuffered version of the squalene o/w emulsion MF59® experienced an unexplained loss in squalene content at 25 or 37 °C over a 3-month period"
    MF59 - tween 20 and span 85. 




  • PharmaPharma Member, Pharmacist
    An unexplained loss... that could mean anything, from oxidation due to poor formulation over an idiot at the work bench to a greedy boss who's not coming up for reference substances... make a pick :smile: .
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