Serum Formulation Oxothiazolidinecarboxylic Acid

Hi Guys,

I am formulating an antioxidant serum. 
I am aware of the patented formula from a renowned company and we are not trying to infringe on their formula. 

Has anyone formulated before with the ingredients listed below and kindly lend some advice? 

The serum will include the following actives:

Oxothiazolidinecarboxylic Acid 2%

3-O-Ethyl ascorbic acid 10%

Alpha arbutin 2%

Ferulic acid 1%

Sodium Hyaluronate 0.5%

Our base will be equal parts 1,3 Propandiol, Glycerin and water q.s 100% preserved with 1% of phenoxyethanol and ethylhexylglycerin (Euxyl PE 9010)


  • PharmaPharma Member, Pharmacist
    edited September 18
    Prashy123 said:
    ...Oxothiazolidinecarboxylic Acid 2%...
    Ah, an interesting ingredient! I'm familiar with N-acetyl-thiazolidine-4-carboxylic acid aka N-ATCA or folcisteine, which is used as plant growth regulator.
    Like N-acetylcysteine ethyl ester aka NACET and N-ATCA, OTCA is one of the more stable cysteine derivatives and used to increase intracellular glutathione. I'm still a bit sceptical since N-ATCA is not just metabolised to cysteine by mitochondria but also to formaldehyde. OTCA on the other hand is said to decarboxylate spontaneously after a first metabolic activation step by 5-oxoprolinase and has been proposed for infusion solutions (dunno if it's actually put to real use).
    Anyway, quite stable molecules and one of the least in your product to cause any issues ;) . Just focus on the others.
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