Urea-ethanol reaction in skin sanitizers

Hello everyone,
I am formulating a liquid spray hand sanitizer containing 63% ethanol, 5% IPA, 2% glycerol and 2% urea. As far as I have tested it, it seems to be Ok, but recently I read about the reaction between ethanol and urea to produce ethyl carbamate, a skin carcinogen molecule. Nevertheless, It appears that such reaction takes place when heating urea and ethanol. My question is if it would be considered as dangerous a cosmetic product containing urea and ethanol?
Thank you all for your comments


  • PharmaPharma Member, Pharmacist
    Unlikely to happen in your case, too much water present and not enough heat.
Sign In or Register to comment.