Home Cosmetic Science Talk Formulating General L vs D for and how it absorbs into the skin

  • L vs D for and how it absorbs into the skin

    Posted by esthetician922 on May 14, 2020 at 8:56 pm

    Do you think it makes a difference if the acid is L or D. Like L Mandelic acid vs D Mandelic and how it would work? I believe the marketing term is chirally correct. 

    doreen replied 3 years, 10 months ago 4 Members · 5 Replies
  • 5 Replies
  • oldperry

    Member
    May 14, 2020 at 9:23 pm

    While chirality makes a difference for drug actives, I’ve not seen any evidence that it matters at all for cosmetic actives.

  • esthetician922

    Member
    May 14, 2020 at 9:30 pm

    Thank you @Perry

  • pharma

    Member
    May 15, 2020 at 4:57 am

    As @Perry said, chirality is important for biological systems and hence pharmaceuticals, but sometimes, just sometimes, chirality has also an effect on physics. Something deep in my brain tells me that there are a few cosmetics ingredients with a mild difference between stereoisomers… it wasn’t simple acids.

  • doreen

    Member
    May 15, 2020 at 10:32 am

    @Pharma
    As far as I know only panthenol (topical), dextro vs levo.

  • doreen

    Member
    May 15, 2020 at 10:34 am

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