Equipment validation and NPD

Do any of you also conduct equipment validation when assessing your lab equipment? 

My vacuum mixer seems not to be drawing a decent vacuum (enough to de-aerate a tooth gel) and just wondering if/how I can validate whether or not I am getting enough vacuum across the mixer. 

To roughly test the vacuum I made a solution of Sorbitol 70% with Silicon Dioxide (Zeodent 117/168) which is a watery gel - and after 60 mins with -200 mmHg it still contains lots of bubbles, after a further 60 mins at -600 mmHg there is no improvement.

Vacuum clearly not working well - but how to validate this?

Comments

  • Bill_TogeBill_Toge Member, Professional Chemist
    a vacuum pump can only do so much; the best way to avoid bubbles is to avoid introducing air into the product in the first place (prevention being better than cure)
    UK based formulation chemist. Strongest subjects: hair styling, hair bleaches, hair dyes (oxidative and non-oxidative) I know some stuff about: EU regulations, emulsions (O/W and W/O), toothpaste, mouthwash, shampoos, other toiletries
  • Bill_Toge said:
    a vacuum pump can only do so much; the best way to avoid bubbles is to avoid introducing air into the product in the first place (prevention being better than cure)
    So true - but it seems my vacuum mixer is whipping more air into the product than I started with. 
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