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Ethanol and Glycerin For Preservation
Hi,
Does anyone know how much ethanol is needed to preserve a liquid formulation if the liquid formula uses 20% glycerin?
20% ethanol seems to be the standard.
I’ve also read an article that says for liquid formulas, 5-10% ethanol is sufficient.
The same article also states that the percentage of ethanol used in a formulation applies to the free water content. So if 100mL of glycerin is used in 500mL solution, the 20% ethanol would apply to the remaining 400mL of solution.
The link to the article I am referring to is listed below:
https://www.researchgate.net/publication/318380276_Antimicrobial_PreservativesAny feedback would be greatly appreciated!
Also, if you have had experience challenge/stability testing with ethanol, please share!
Thank you!
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