Using Niacinamide and Vitamin C together in formulations

nullafullanullafulla Member
edited September 2019 in Formulating
Hi all

As the discussion title suggests, I'm interested in finding out whether Vitamin B3 and Vitamin C are ok to use together or whether they cause flushing as some internet "blogs" suggest. I just know how "factual" some of these blogs are..

You get one blog that suggests they should not be put together due to x,y,z  issues. Then read another and get the opposite info.. I'm searching through some clinical studies now.

I'm wondering if anyone can provide any of your own knowledge/experience and/or links to clinical studies to show results to either confirm they should/ should not be formulated together.

Also, will 'Sodium Ascorbyl Phosphate' oxidise like other forms of Vitamin C?  As I'm led to believe it's a more stable version of Vit C, but I've found that my formula change colour after a couple months. Any suggestions to slow the oxidisation process in water soluble formula? I've seen Rosamox suggested prior, I've contacted the manufacturer without response, so wondering if there's  any other suggestions.

Thanks in advance for any help :)


  • Bill_TogeBill_Toge Member, Professional Chemist
    sodium ascorbyl 2-phosphate will oxidise, but at a much slower rate than vitamin C - whether or not this leads to visible discolouration depends on how much you have in the formula
    if you keep your formula free of metal ions (i.e. used deionised water and a chelator) that will slow down the oxidation further
    UK based formulation chemist. Strongest subjects: hair styling, hair bleaches, hair dyes (oxidative and non-oxidative) I know some stuff about: EU regulations, emulsions (O/W and W/O), toothpaste, mouthwash, shampoos, other toiletries
  • Bill_Toge Thank you very much for your time and info :)

    There's 2% Sodium Ascorbyl Phosphate.

    I've been using reverse osmosis water. I'll add in Disodium EDTA as a chelator to test results.

    I've read that sodium metabisulfite might be an option to help reduce oxidation of the formula. Do you recommend giving that or something similar a try?

    Also, I'm wondering as you're a professional chemist, do you have an opinion on using Vit C and Vit B3 together, as there's so much conflicting information. 

    Thanks again for your time
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