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Ascorbyl Palmitate
I was thinking using Ascorbyl Palmitate at 0.1% for synergistic
antioxidant action with tocopherol, against rancidity in creams. Now I
think I will use only tocopherol.
It’s an old (2002) study but very interesting:
http://www.jidonline.org/article/S0022-202X%2815%2930060-9/pdfhttp://www.jidonline.org/article/S0022-202X%2815%2930060-9/fulltext
In summary, at concentrations exceeding 100–300 μM the potential damage
induced by the oxidant properties of AA6P probably outweighs the
benefits of its antioxidant potential. Lower AA6P doses (3–30 μM) seemed
to have no significant protective effect on keratinocyte viability
although the ascorbyl group was effective in scavenging intracellular
ROS. At higher concentrations, the lipid component promoted UVB-induced
LPO and the formation of cytotoxic oxidized lipid compounds (Figure 5).
AA6P may effectively protect against ROS and oxidant agents that do not
exploit the oxidant properties of AA6P by targeting cellular lipids.
Oxidative-stress-induced signaling pathway activation, however, which
underlies acute and chronic skin responses to UV radiation, including
solar erythema, skin aging, and carcinogenesis, may be negatively
influenced by the vitamin C derivative ascorbyl palmitate.
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