Cocamidopropyl Betaine (CAPB) Manufacturing

Dear all, being trying to find out for weeks on how can i produce CAPB.

So far what i managed to find out from the internet and books is that that "Cocamidopropyl betaine production starts by reacting coconut oil fatty acids with 3,3-dimethylaminopropylamine, which yields cocamidopropyl dimethylamine. Cocamidopropyl dimethylamine is then reacted with sodium monochloroacetate to produce cocamidopropyl betaine."

However, it does not mentions the molar ratios, the process parameters and reaction times for both stages. Can someone please guide me as to how or whom might be able to help me find these information please? 


  • handbook of detergents part f production

  • edited September 2018
    In what kind of setting to you plan on doing this synthesis?  Some of the compounds that you mentioned have significant hazards associated with them.
  • BelassiBelassi Member, PCF student
    If you're going to these lengths, you may as well make MDMA instead, it's more profitable.
    Cosmetic Brand Creation. Concept to name to IMPI search to logo and brand registration. In-house graphic design inc. Pantone specs. Cosmetic label and box design & graphics.
  • MicroformulationMicroformulation Member, Professional Chemist
    edited September 2018
    @Belassi I couldn't agree more! If you are going to do an elegant chemical synthesis, why waste it on CAPB?

    I am more focused on creating the end product for the client, not synthesizing common ingredients. I could get on Prospector and have any number of samples of CAPB in varying forms. I can also purchase from any number of manufacturers. Microformulation Cosmetic Consulting provides Custom Formulations for both large Commercial accounts as well as smaller entrepreneurs. We can provide Naturally compliant Formulations under the NSF, NPA, Whole Foods and USDA Organic Certifications. BS.Pharm Albany College of Pharmacy, Union University.
  • @sendtoryan CAPB manufacturing requires hard to source, dangerous chemicals and maybe expensive equipment for safety.

    You'll need to make a lot of it to be profitable.
    I can get some nice, generic chinese CAPB for $2.50 per Kilo, retail price by the Kg. Even cheaper by the drum.

    LOL @ CAPB Heisenberg (Breaking Bad).
    ROFL this one really made me laugh.
  • Why make when it is so cheap and available in tons?
  • Thanks all for response..after speaking to various chinese and indian suppliers, they all told me that CAPB was widely used and in large quantities therefore i thought that if manufactured on a large scale it would make sense..

    Would MES be a more attractive opinon then? However capital equipment investment for MES is in the millions region..
  • Sorry i didnt clarify myself. We run a very small family business manufacturing kde and cde at the moment. So looking into possibilities into expanding the business alittle. 
  • Breaking Bad!
    Dr. Catherine Pratt
    (B.Sc with HONS I , Ph.D Analytical/Organic Chem and Microbiology), Cosmetic Chemistry IPCS)
  • Right now im making 70%-80% glycerin from spent lye of soap synthesys and ussing it to make ethyleneglycol estearate/diestearare , in my country where is very diffcult to find any foreing currency its very profitable to make our own raw materials, in fact some times making our own raw materials is the only way to obtain they. i have bought Betaine from 5-6$/kilogram.  
  • DASDAS Member
    edited November 2018
    OMG what a scam.

    Supply and demand is a bitch.

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