Home Cosmetic Science Talk Formulating Advanced Questions Would Benzoyl Peroxide oxidize Chlorhexidine Gluconate in a gel?

  • Would Benzoyl Peroxide oxidize Chlorhexidine Gluconate in a gel?

    Posted by zink on September 27, 2016 at 5:55 am

    It seems like the amine groups in Chlorhexidine could be oxidized, but maybe it could be avoided with the right formulation. The intended application would be for pets.

    zink replied 7 years, 5 months ago 3 Members · 4 Replies
  • 4 Replies
  • bill_toge

    Member
    September 27, 2016 at 7:05 am

    probably not; all the nitrogens are part of a conjugated biguanidine system (so they wouldn’t react like amines), and one is conjugated with the benzene ring, making it even less reactive

    as ever, the best way to find out would be to try it and see!

  • zink

    Member
    October 4, 2016 at 6:53 am

    Thanks Bill! I guess you could make two samples with and wo Chlorhexidine, incubate them at 40C for a week and have the Benzoyl Peroxide % assayed by HPLC ($125/sample)?

  • johnb

    Member
    October 4, 2016 at 8:02 am

    Where would you be selling this product?

    Take great care that you comply with licensing requirements for your marketplace.

    Do you know if the combination you are suggesting is effective? There are gazillions of products already on the market so your effort would have to be something pretty special - which, with all due respect, I don’t think it is.

  • zink

    Member
    October 5, 2016 at 6:49 am

    Yes, nothing special here, move along..

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