Glutathione use in cosmetics

I wanted to incorporate glutathione in my cream formulation. What should I choose reduced glutathione or glutathione itself. Does it have any storage problem?


  • PerryPerry Administrator, Professional Chemist
    What do you want the Glutathione to do in your formula?

    If it is just a marketing ingredient choose the one that is the least expensive.
  • RubenRuben Member
    If you plan to use it as an antioxidant I'd think you need the reduced form
  • I wanted to incorporate glutathione as an anti agieng agent. I have had data where many formulators claim of using glutathione and not specifically reduced form, is it a bluff in labelling?Thanks for your response. 
  • BobzchemistBobzchemist Member, PCF student
    Try it both ways and see for yourself.
    Robert Zonis, Sr. Formulation Chemist, Beaumont Products "All opinions and comments expressed are my own, have no relation to Beaumont Products, are fully copyrighted, and may not be used without written permission."
  • PerryPerry Administrator, Professional Chemist
    I did a little searching through the literature but could not find any peer reviewed research on the benefits of topically applied glutathione.  Do you have any kind of link?
  • I will share the proceedings for this glutathione product.. No peer reviewed literature for it as far its conformation of being antiageing is available. Needs research I guess. I will get back with data achieved using glutathione as antiageing. Thanks for help

  • PharmaPharma Member, Pharmacist
    Glutathione doesn't penetrate into the skin (unless you use fancy-shmancy hightech stuff). It is also highly susceptible to oxidation (the reduced, active form) and will degrade very fast once put into solution. It's just an expensive claim ingredient ;) .
    If you want something similar with a slightly increased availability (though not much), go with N-acetylcysteine. It is the protected and hence more lipophilic part of glutathione which makes it a good antioxidant and anti-aging product. If you added glycine and glutamic acid at equal molare ratios, you could claim that your product contains the building blocks of glutathione and that the skin will form it (which is true, on a theoretical and/or in vitro level)...
  • Thanks a lot..  :)
Sign In or Register to comment.