Molecular weight < 500 Da can be absorbed into skin

incredient that has less than 500 Da molecular weight can be absorbed to skin. 
Hyaluronic acids medium, small and very small have molecular weight > 500 Da. Therefore they can not be absorbed to skin? But, it works well on the skin.
why? I appreciate all answers 

Thank you so much and have good weekend.


  • PerryPerry Administrator, Professional Chemist
    It’s a good humectant on the upper layers of the skin
  • MarkBroussardMarkBroussard Member, Professional Chemist

    Molecular weight is only one factor that determines if a particular ingredient can penetrate the SC.  The super low molecular weight HA does indeed penetrate with the optimal being 200 kDa for HA.
    Chemist/Microbiologist formulating in the Organic & Naturals & Clean Beauty arena under ECOCert/Natural Products Assn/Whole Foods/National Organic Program/Clean At Sephora/Credo Clean guidelines focused skincare & haircare products. 

    See website for details
  • DtdangDtdang Member
    @Perry, @MarkBroussard
    Thank you so much 😊!
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