Can Magnesium Ascorbyl Phosphate Be Made at Home?

Good morning Everyone. I like doing diy's, and have a question regarding the compound for Magnesium Ascorbyl Phosphate aka (MAP.) I am trying to make my own at home and I was wondering if it is something that I can do myself.

I found that the compound for Magnesium Ascorbyl Phosphate is C6H7MgO9P. Is it possible to combine the compound Ascorbic Acid C6H8O6 and Magnesium Glycerophosphate C3H7MgO6P to arrive at Magnesium Ascorbyl Phosphate seeing that they both have the same elements in the compound apart from one, Phosphate, and the subscripts are not the same for the like elements? If so, what is the ratio amount or percentage of each when combining the two?

Thank you in advance,


  • MicroformulationMicroformulation Member, Professional Chemist
    Why? Just why would you even try that? Buy the material. The synthesis process that you are referring to is far beyond the capabilities of anyone without specialized training and equipment. Microformulation Cosmetic Consulting provides Custom Formulations for both large Commercial accounts as well as smaller entrepreneurs. We can provide Naturally compliant Formulations under the NSF, NPA, Whole Foods and USDA Organic Certifications. BS.Pharm Albany College of Pharmacy, Union University.
  • PerryPerry Administrator, Professional Chemist
    @Microformulation - yeah I agree. I remember synthesizing a lot of ingredients in Organic Chemistry (even DEET). But I never thought it was a good idea to put it on my skin!

    Mixing cosmetic ingredients in beakers at home is fine. Conducting organic synthesis then using the ingredients...that's a bit less fine.

  • Sorry for the off topic but I think chemists would enjoy this channel:
    Nile Red
  • And regarding MAP it isn’t even worth the effort. It oxidises despite all claims, and there’s not enough evidence it does anything beneficial for skin. Why bother?
  • emma1985emma1985 Member
    edited March 29
    I agree with ngarayeva. There's almost 0 research supporting the idea that MAP concerts to Ascorbic Acid on the skin (which it must do to provide benefit.) Check out cosmetic chemist Stephen Ko's write up on Vitamin C derivatives. Bottom line is they probably don't work. The only one with SOME promise is Tetrahexyldecyl Ascorbate (Ascorbyl Tetraisopalmitate.)

  • "I find the evidence for Ascorbic Acid derivatives pretty unconvincing. They're a great way to market a product as Vitamin C, but the evidence that they provide the same benefit as Ascorbic Acid just isn't there."
  • PerryPerry Administrator, Professional Chemist
    @emma1985 - How do you feel about the evidence of the effectiveness of Ascorbic Acid? 

  • k_wk_w Member
    Thank you all so much for your quick replies, and your expert knowledge. Much appreciated.  
  • @Perry define ‘effectiveness’ 😜 sorry, I couldn’t resist :)
  • Perry said:
    @emma1985 - How do you feel about the evidence of the effectiveness of Ascorbic Acid? 

    I'm no expert but aqueous Ascorbic Acid at 10-20%, formulated at a pH of under 3.5 and with supporting antioxidants (Vitamin E and Ferulic Acid) seems pretty evidence-based to me, based on the research done initially by Dr. Pinnell and his team, and other teams since then.

    Anecdotally, I've been using Ascorbic Acid daily for many years and I do think it helps with general skin brightening.

    Obviously I have no way to test if it's doing what it's ultimately supposed to above anything else; attenuating free radical damage.
  • @emma1985 I tried all derivatives I could put my hands on and they all were highly disappointing. I even recreated CE Ferulic but my final conclusion is it’s easier to make 20% LAA solution every two (3 if I am lazy) weeks and keep it in the fridge. I don’t use it all the time but I have a subjective perception that it improves my skin colour. This thread reminded me I should make some :) 
  • PerryPerry Administrator, Professional Chemist
    @emma1985 - In truth, I'm not really an expert on the subject either which is the main reason I asked.

    I find most of the published research on anti-aging ingredients disappointing. Even the double-blind placebo controlled stuff (which is very few). Mostly because they never seem to pick a placebo that contains a well-formulated petrolatum base moisturizer.

    These studies always seem to pick weak controls so they can show bigger differences. That is great for advertising copy & getting patents, but for answering the question "Is there any real additional benefit to using this product over a standard moisturizer?" it's not really helpful.
  • k_wk_w Member
    You all are great! Thanks again.   o:)
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