Chelating agent as preservative booster. How and against which organisms

AbdullahAbdullah Member
in Advanced Questions
Against which organisms does chelating agents boost preservative effectiveness?
And by which mechanism?

One that i know is against aeruginosa by chelating calcium from its biofilm so preservative can penetrate better and work better.

What more.
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Comments

  • PhilGeisPhilGeis Member, Professional formulator
    That is certianly one.  Also offers competition for other trace elements - Fe, Mg, CU.
  • AbdullahAbdullah Member
    @PhilGeis thanks 
    Will this mechanism effect all microorganisms or some of them
  • GraillotionGraillotion Member
    PhilGeis said:
    That is certianly one.  Also offers competition for other trace elements - Fe, Mg, CU.
    Speaking of the metals....how about Silver?  Before you start swearing... I am using silver citrate at a low rate in a deo product, NOT as a preservative.

    So I have read slightly conflicting thoughts amongst Phd's on silver citrate in relationship to chelation.  So I was curious if you could weigh in on the topic.  One respected Phd basically said...without giving any details.... Silver Citrate and chelation don't mix.  The other one....which I consider one of the most brilliant minds on the planet said this: Silver ions carry a single positive charge and, according to the HSAB system, are 'soft acids' which have a high preference for 'soft bases' such as thiols. Simply put, silver is a .... poor ligand for most chelates and will not interfere with GLDA or EDTA. These chelates may bind to the surface of colloidal silver particles but, unlike zinc, the effect isn't strong enough to neutralise anything.

    I am typically using GLDA as my chelate...but also have sodium phytate on hand.... so could switch if need be.

    Aloha @PhilGeis  
  • PhilGeisPhilGeis Member, Professional formulator
    Abdullah said:
    @PhilGeis thanks 
    Will this mechanism effect all microorganisms or some of them
    Not much info. Microbial dynamics can be different.  EDTA by itself is not a preservative.
  • PharmaPharma Member, Pharmacist
    Graillotion said:
    ...
    I am typically using GLDA as my chelate...but also have sodium phytate on hand.... so could switch if need be.
    ...
    Do not use phytate with silver (or any other metals). Phytate forms insoluble salts with most metals (in case of monovalent ones not chelates but that doesn't change much).
  • GraillotionGraillotion Member
    Pharma said:
    ...
    I am typically using GLDA as my chelate...but also have sodium phytate on hand.... so could switch if need be.
    ...
    Do not use phytate with silver (or any other metals). Phytate forms insoluble salts with most metals (in case of monovalent ones not chelates but that doesn't change much).
    Guete Morge

    Thank you for your brilliance....you input is of immeasurable value.

    Guet, merci
  • PharmaPharma Member, Pharmacist
    LoL! You're taking Swiss German classes, nice :smiley: !
    BTW at this late time of the day it's 'guete Abe' ;) .
  • GraillotionGraillotion Member
    Pharma 
    BTW at this late time of the day it's 'guete Abe' ;) .
    Actually....depends on who's timetable we used.... As you know....we are exactly opposites....hehehe....12 hours apart.
  • PharmaPharma Member, Pharmacist
    Graillotion said:
    Pharma 
    BTW at this late time of the day it's 'guete Abe' ;) .
    Actually....depends on who's timetable we used.... As you know....we are exactly opposites....hehehe....12 hours apart.
    Just trying to boost not only preservation but also your vocabulary in a subtile way... guess it didn't work, or did it?
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