What is the ionic charge of Parabens like methyl Paraben?

AbdullahAbdullah Member
edited November 2021 in Formulating
What is the ionic charge of Parabens?

Are they compatible with cationic surfactants?

Ulprospector says Paraben is incompatible with most of cationic and non-ionic surfactants, cellulose esters, PEG and gelatins.

Comments

  • PharmaPharma Member, Pharmacist
    None to partially negative, depends ;) .
    Incompatibility has nothing to do with 'ionic charge'.
  • AbdullahAbdullah Member
    edited November 2021
    @Pharma anionics like sodium benzoate doesn't work well with cationic surfactants like SPDMA. Will it be the same for methyl Paraben at pH 4-5?

    How "Incompatibility has nothing to do with 'ionic charge'."?
  • PharmaPharma Member, Pharmacist
    The incompatibility of parabens has something to do with overall structure (especially the aromatic part) and is a thing of observation because there is no clear scientific explanation why and how.
    Ionic interactions like benzoate with cationic emulsifiers clearly depend on the charge.
  • Pharma said:
    The incompatibility of parabens has something to do with overall structure (especially the aromatic part) and is a thing of observation because there is no clear scientific explanation why and how.
    Ionic interactions like benzoate with cationic emulsifiers clearly depend on the charge.
    Thanks
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