Which is the better penetration enhancer?

Propanediol or MSM


  • PharmaPharma Member, Pharmacist
    Neither. Propanediol is just a protic solvent and MSM a solid which, due its close relation to DMSO, is often called a penetration enhancer without reliable citation. MSM may have other effects on skin penetration as you can read HERE (not saying that this is a reliable source nor that the results may be extrapolated).
  • You could look at a small amount of squalane, or glyceryl oleate.
  • I don't think either are true penetration enhancers the way Dimethyl Isosorbide is, for example. It's like when people say glycerin is a penetration enhancer. 
  • Look up forum’s archives. It was discussed many times.
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