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healing cream
I want to make a cream or gel with wound healing or toughening for rough sports. Any suggested raw materials that would be useful in skin healing after being torn, cut, bruised?
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23 Replies
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There are grades of Hyaluronic Acid that are used in Wound Healing … about 200 kDa molecular weight. GHK-Cu is also useful to stimulate wound healing.
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Hi @MarkBroussard I always learn something new on this website. Thanks Mark I have never heard of GHK-Cu until now (had to google!) - They sell small quantities of it at MSR in Thailand (just looked up) and the solution of 1000ppm is about $17 (AUD) for 50g. How much of the solution would you recommend in a healing cream product? Does it color your skin (as the powder is blue and wow so expensive but I guess you don’t need much of that as cost is around $340 (AUD) per gram! Also (probably dumb question) how does the 200 kDa H Acid help with wound healing - is it the H Acid itself or is it because it is absorbed into your skin better so any actives go into skin to help with wound healing. I recently gave myself a 2nd degree burn cooking on my hand on palm near index finger and it is taking forever to heal - any suggestions for good OTC products available in Australia (my local Chemist was not very helpful.). I also tend to give myself (not on purpose!) cuts on my hands so any advice on what is best for these too ? Thanks for any advice
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7950635/
Just hydrate 1% to 2% 200 kDa HA directly in the 1000 ppm GHK-Cu solution and you have a healing gel … add preservatives, of course.
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MarkBroussard said:http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7950635/
Just hydrate 1% to 2% 200 kDa HA directly in the 1000 ppm GHK-Cu solution and you have a healing gel … add preservatives, of course.
Mark you are a legend! Thanks so much, you have made my day.
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If you’re in US, this is would be a drug product.
Regulatory status aside, how do you propose to prove ‘healing” efficacy? -
@PhilGeis
I understand the scope of your question but honestly haven’t thought that far. I would assume by each person’s experience. They would apply the product on a torn/lacerated part of the body and see how fast the healing would result. Any suggestions? -
@GoldenFish - if it’s just based on people’s experience you don’t need anything more than a good moisturizer. You can put in other ingredients for a story & tell people it helps healing.
You have to remember there are three things that can happen with any condition that is untreated
1. it gets better
2. it gets worse
3. there’s no changeThese are exactly the same things that can happen to the condition after any treatment.
If you want to make a product that really works you’ll need a placebo controlled, double blinded study to demonstrate effectiveness. If you don’t want the expense & rigor of this, just create a good moisturizer with story ingredients.
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@Perry
Thanks! I would like a little effectiveness since I want to market toward a sports niche that constantly experiences torn flesh/bruising. -
If you make a good moisturizer that is pleasant to use with a good fragrance & interesting packaging plus create a good story about how the product could help, that’s all you need. The formulating part is not the hard part.
Even if you could make a product that speeds healing by 50%, if you don’t have a compelling story and a product that is aesthetically pleasing to use, it’s unlikely people will buy it. In the cosmetics industry, story beats formula function.
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An open wound (cut, scrape, etc.) is very different from a bruise or a torn ligament. Don’t think you’re going to find one formulation that will address all three issues.
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MarkBroussard said:http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7950635/
Just hydrate 1% to 2% 200 kDa HA directly in the 1000 ppm GHK-Cu solution and you have a healing gel … add preservatives, of course.
Hey Mark just letting you know (I plan to buy some of the 1000 pm GHK-Cu in January - too busy before Xmas right now with other stuff) but I made and used some HA directly on my cut (it wasn’t deep) and it closed over and healed in 2 days which is amazing for me - so thanks so much for sharing. Looking forward to making myself the healing gel you suggested next year. Cheers and Merry Xmas if I don’t correspond again beforehand.
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My pleasure. Glad to hear that you had a good experience with HA alone. I think you will be quite pleased with the HA/GHK-Cu combation.
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@MarkBroussard
thanks… I wanted this to address regular skin trauma that is experienced by athletes or very physical people. I am not trying to mend torn ligaments or contusions. -
Yes, I understand that aspect of it … that would be a “sports cream” that provides some pain relief. Think Menthol, CBD, etc.
The HA/GHK-Cu is more oriented towards cuts, burns, scrapes and would provide no pain relief to bruises, etc.
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Hi @MarkBroussard - If you can advise me a little more that would be great and if not no problem :smile:I bought a small amount 100 ml of the GHK-Cu 1000 ppm solution but didn’t want to use all at once. I have also bought afew different kDa of Hyaluronic Acid (HA) as couldn’t just but 200 kDa. So I have bought a small molecule powder of 100 kDa (says it may be between 80 and 150) but I also bought a liquid of 4D Hyaluronic liquid (that says is a combo of 4 different weights). Just wondering if you could suggest % of each - this is what I was going to try (but would like advice as didn’t want to waste ingredients) -
GHK-Co 1000 ppm Solution 93.5% approx
100 kDa 100 kDa - 0.50%
4d HA liquid - 5%
Preservative like PlantaservE - 1% or better suggestion?
A thicken like Xanthan Gum Clear or Hydroxyethylcellulose ? 0.3%
I also plan to keep in fridge at about 10 to 12 degrees (my wine fridge)
Thoughts? Also maybe adding 0.3 to 0.5% allantoin or calendula extract or is this being a bit silly?
Many thanks if you have time to answer (It is only for me and dont plan to sell). Cheers
If anyone else has further suggestions happy to hear those also. -
You are fine on the GHK-Cu and 100 kDa HA. You’re not going to get much thickening from the 100 kDa HA. You can use the 4D HA for that purpose. Try starting the 4D HA at 0.5% to see if you get enough viscosity build. If not, add a bit more in 0.2% increments. If your 4D HA is viscous enough, you won’t need an additional thickener such as Xanthan or HEC.
Don’t bother with the Allantoin or Calendula … they really won’t do anything.
The HA will bind with Fibrinogen to help form the fibrin clot and the GHK-Cu acts as a signal molecule to stimulate an immune response.
Yes, PlantaserveE at 0.7% would be fine. You could complement with 0.3% Sodium Benzoate should do the trick.
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Mark thanks so much for your time and advice. Thats what I thought about the 100 kDa HA regarding it being too thin, which is why I thought I’d add the 4D HA so thanks for advice on %’s to try. I have Sodium Benzoate too so will add as suggested. I’m off to make my little batch now based on your suggestions and I’ll let you know how I go. So excited!!! Happy New Year
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@MarkBroussard
Hi again Mark well I made a very small batch and ended up using a small amount of Xanthan Gum Clear to get the consistency I wanted. Will test out as we need it and see what we think. Thanks so much will all your help with this it is really appreciated. Cheers. -
My pleasure. You can also use it as a kick-ass facial serum … don’t necessarily need to apply it on a wound.
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@MarkBroussard yes I thought so to so thanks for confirming that. I am just using a little at moment to test under my eyes (dont worry not getting in eyes) as I have fine wrinkles there and I dont know if my imagination but they appear a little less - I’m lucky I dont really have wrinkles at my age I’m pretty happy with. As for it working for wounds I am really impressed with the results and so is my partner - Thanks heaps for everything really appreciate it. I learn so much from you answering other people’s queries too.
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btw Squinny
PlantserveE is not enough - you need something for fungi/Gram +’s as Mark said and at a proper pH -
Thanks @PhilGeis I did that too. I’m a lot more aware of Preservatives and pH after being on this forum. Appreciate your advice. Cheers and happy 2023.
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