Dimethyl Isosorbide - Better than Propylene Glycol as a Benzoyl Peroxide solvent & penetration aid?

Gransolve toutes that DMI is a great solvent to solvate and increase skin penetration of Benzoyl Peroxide and other actives. It's very expensive at $230 for 16 fl.oz, and mouse data indicate that it doesn't penetrate the skin any better than PG http://www.sciencedirect.com/science/article/pii/S0939641198000307

So - why not just stick to PG?


  • Because PG has a poor reputation among the masses as 'anti-freeze' hence the alternatives are often explored.
  • ZinkZink Member
    Or why not Butylene Glycol ;)
  • isnt DMI better for dissolving Benzyl peroxide than PG?
  • Any word on whats better between DMI and PG? 
  • 1,3 Propanediol should at least be similar toPG!
  • I believe DMI is better for dissolving and possibly also stabilizing BP. That being said I haven't done any empirical testing, but it wouldn't be too expensive, BP HPLC analysis is only $120 with Custom Analytics. 
  • DMI will give an odor:found Grant to be best.
  • MarkBroussardMarkBroussard Member, Professional Chemist
    Yes, I have had not one client elect to use DMI (the Grant product) after they get a whiff of their product into which DMI has been incorporated.  So, I simply no longer consider it as an ingredient option.
    Chemist/Microbiologist formulating in the Organic & Naturals arena under ECOCert/Natural Products Assn/Whole Foods/National Organic Program guidelines focused skincare & haircare products. 

    See website for details www.desertinbloomcosmeticslab.com
  • What about DMSO "dimethyl sulfoxide", has it been used in cosmetic as solvent?
    I did use it experimentally in lab animals during my studies as solvent for some herb oil extracts and also in formulating topical pesticides for pets (as skin penetration aid)
  • BelassiBelassi Member, PCF student
    What about DMSO "dimethyl sulfoxide", has it been used in cosmetic as solvent?
    Really? If you put it on your skin, reportedly, you will taste it pretty rapidly.
    Cosmetic Brand Creation. Concept to name to IMPI search to logo and brand registration. In-house graphic design inc. Pantone specs. Cosmetic label and box design & graphics.
  • Bill_TogeBill_Toge Member, Professional Chemist
    @zaidjeber not in Europe; it's been banned from cosmetics there since 1979
    UK based formulation chemist. Strongest subjects: hair styling, hair bleaches, hair dyes (oxidative and non-oxidative) I know some stuff about: EU regulations, emulsions (O/W and W/O), toothpaste, mouthwash, shampoos, other toiletries
  • @zaidjeber nope, not ok to use in the US in cosmetics, which doesn't stop some brand from selling DMSO cream "not for cosmetic use"

    The scent of DMI can be masked, really depends how much you're using.
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