• Hair Growth Oil

    Posted by Anonymous on December 14, 2018 at 4:56 am

    Hi. I am working on an oil based formulation for Hair treatment and Hair Growth using Essential Oils and Extracts. Kindly help me fining the right and effective ingredients for the purpose.

    Sibech replied 5 years, 3 months ago 7 Members · 11 Replies
  • 11 Replies
  • EVchem

    Member
    December 14, 2018 at 3:30 pm

    Is this just for your personal use? I don’t really know if hair growth falls under cosmetic or drug category, and I wouldn’t expect very substantial results with extracts and oils that are probably not standardized. 

    That said, a couple products that are used for these types of requests:
    Pisum Sativum (Pea) Sprout Extract
    Vitis Vinifera Fruit Meristem Cell Culture (and) Hydrolyzed Eruca Sativa Leaf (and) Hydrolyzed Walnut Extract
    Humulus Lupulus (Hops) Extract
    Capsicum Frutescens Fruit Extract
     Larix Europaea Wood Extract 

    all I did was search “hair growth” on UL prospector.

  • oldperry

    Member
    December 14, 2018 at 3:35 pm

    Hair growth is a drug product. If it works, it’s a drug.  It doesn’t matter whether the materials are natural, plant extracts or advanced, synthetic compounds. 

    Here is the monograph for hair growth products.

    The only proven ingredients are Minoxidyl and Propecia. 

    If you want to create a product that doesn’t work but makes you feel like it’s working follow the suggestions by @EVchem

  • gunther

    Member
    December 15, 2018 at 6:40 pm

    There’s a study that suggests that 2% peppermint oil helps with baldness.
    Google it.

  • oldperry

    Member
    December 15, 2018 at 7:42 pm

    For the curious, here is a link to the mouse study demonstrating an effect of peppermint oil on hair growth.  There is another study that seems incredibly similar suggesting 3 - 5% Lavender oil could have an effect. 

    This research is interesting, but it was done in mice which doesn’t always translate to effects in humans. 

    It seems weird to me that Minoxidil which only works in about 66% of people, showed 100% effectiveness in these mouse models. This shows that the research model clearly exaggerates the effect.

  • david

    Member
    December 17, 2018 at 10:27 pm

    I agree the peppermint oil paper/research has flaws, but what buggles me is: who would spend vast resources to really prove that something that you can buy in the supermarket works as good as a patented molecule for a given medical application?

  • oldperry

    Member
    December 18, 2018 at 1:05 am

    @David - Universities would do that or maybe some governments.

    I suspect all the big companies have already done this type of research and haven’t published anything. Most likely because they haven’t found something that really works.

  • david

    Member
    December 18, 2018 at 2:59 pm

    @Perry -yeah, that makes sense I guess. It would however be great if people could publish also “negative” results. This would correct the bias.
     

  • oldperry

    Member
    December 18, 2018 at 3:32 pm

    @David - it would be nice but this is actually a common problem in all science.  It’s even got a name : the file-drawer effect

    This is why I am skeptical of any single study that shows some dramatic effect. There could have been dozens of studies that looked at the same compound which showed no effect and just weren’t published.

    Extraordinary claims require extraordinary proof.

  • microformulation

    Member
    December 18, 2018 at 4:30 pm
    This is a frustration for many Formulators. When discussing a raw material, the client will cite one of these small studies. Unfortunately, they submit these small studies as “proof” that they can make claims.
  • belassi

    Member
    December 18, 2018 at 5:45 pm

    Exactly. Remember when I discovered that study on hair loss in rats, and made an experimental project to see if I could develop a new depilatory product. It didn’t work. If anything it promoted hair growth. Rats are not people.

  • Sibech

    Member
    December 18, 2018 at 9:04 pm
    The hair cycle growth is so complicated that you cannot reasonably expect hair to grow based on a single molecule. Some of the hormones/signalling molecules are important for growth but just as important for halting the same growth, depending on the phase of the hair cycle.
    The actual mechanism of action for Minoxidil is still to be properly elucidated. Current knowledge indicates an increase in cellular calcium influx and vasodilation as the major causes of effectiveness. Of course, I cannot exclude other mechanisms of action to be, at least partly, responsible for the effect. However stipulating on these effects being of importance, I would expect to see the same effect from the high-concentration essential oils as they would probably cause local irritation which can induce the same two responses.
    DHT is one of the key factors in androgen alopecia (male pattern baldness). The active of Propecia compound Finasteride is a 5alpha-reductase II and III inhibitor, meaning that it stops the enzyme responsible for the production of DHT from testosterone. However, it is worth noting that Finasteride needs to be taken orally, not topically to actually function and it has a 3 month period of use before any results are expected to be observed.
    Now, it is conceivably plausible to inhibit 5alpha-reductase using phytochemicals and a myriad of articles citing phytochemicals as hair growth promoters would suggest the same. Usually, the studies are performed on rats or in vitro and commonly the studies report polyphenols (chalcones and flavones usually) as the active principle. However, most of the extracts/phytochemicals have about 1-2 studies supporting the notion in rats or in vitro. Few if any, of these studies, have been repeated in human models and as many have commented, rats are not humans.
    Entertaining the notion that polyphenols should reliably reduce DHT production and halt hair loss, you might wonder why healthy men eating plenty of fruit and drinking green tea daily, might still lose their hair?
    Granted, there are raw materials on the market touting effect here, but clinical significance in vivo/in vitro does not necessarily mean any noticeable effect.

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