Zinc Oxide / Calamine cream - Cosmetic Science Talk

Zinc Oxide / Calamine cream

Has anyone worked with this before?  Just curious if there are any tips with working with ZnO/Calamine.  Thank you

Comments

  • edited September 13
    I have some and also experimenting with it.  
  • I have worked with it as I have come up through Pharmacy Compounding. If you want some guidance on working with it, look at some of the many Formulations that are posted for Pharmacy compounding as well as the USP/NF documents. Remington: The Science and Practice of Pharmacy covers it quite a bit.

    markfuller@microformulation.com Microformulation.com Microformulation Cosmetic Consulting provides Custom Formulations for both large Commercial accounts as well as smaller entrepreneurs. We can provide Naturally compliant Formulations under the NSF, NPA, Whole Foods and USDA Organic Certifications.
  • @Microformulation thanks ill look at that book.  I had been attempting a petrolatum paste with ZnO at 20% with calamine.  Looks smooth until it cools and then it seems gritty.  
  • In Pharmaceutical compounding we made small batches and honestly only when the mass produced OTC was deviated from.

    Your issues are thus;
    -If you are in the US, it is an OTC product. That means you must follow an OTC monograph and with the Regulatory requirements, it is not a Cosmetic nor is it feasible for a Cosmetic line to Market.
    -The USP OTC percentage is 8% and that was a bear to get incorporated if I recall correctly. Why 20%? In Pharmacy Compounding we were able to deviate from the OTC monograph since I prescription was provided, there were Journal citations for the Physician to justify the higher percentage and it properly became a Prescription Drug evolution. Even so, I never made higher than 12% and that was a challenge. In the end, the sensorials were not what I would have liked. 
    markfuller@microformulation.com Microformulation.com Microformulation Cosmetic Consulting provides Custom Formulations for both large Commercial accounts as well as smaller entrepreneurs. We can provide Naturally compliant Formulations under the NSF, NPA, Whole Foods and USDA Organic Certifications.
  • markfuller@microformulation.com Microformulation.com Microformulation Cosmetic Consulting provides Custom Formulations for both large Commercial accounts as well as smaller entrepreneurs. We can provide Naturally compliant Formulations under the NSF, NPA, Whole Foods and USDA Organic Certifications.
  • @Microformulation
    thanks for the info, i am aware and i am fully compliant with all otc requirements. 
  • edited September 13
    1-25% is in the monograph but difficult to obtain and as such, I can't recall any products that go that high. I do recall 20% ZnO with 1% Calamine.


    markfuller@microformulation.com Microformulation.com Microformulation Cosmetic Consulting provides Custom Formulations for both large Commercial accounts as well as smaller entrepreneurs. We can provide Naturally compliant Formulations under the NSF, NPA, Whole Foods and USDA Organic Certifications.
  • If I had to guess, I'd say your ZnO was re-agglomerating. What are you using to mill this with?
    Robert Zonis, Sr. Formulation Chemist, Beaumont Products "All opinions and comments expressed are my own, have no relation to Beaumont Products, are fully copyrighted, and may not be used without written permission."
  • edited September 14
    @Bobzchemist hey thanks for the reply.  I am just doing lab samples right now using lab stick homogenizer.  I'll look into agglomeration.  Anything you can think of to help with that issue? Thanks
  • High-speed (Cowles) disperser, 3-roll mill, colloid mill or ball mill. You could even use a muller if your sample size is small enough. Stick homogenizers don't generate nearly enough shear force.

    There are also grades of ZnO and/or dispersing agents that should help.
    Robert Zonis, Sr. Formulation Chemist, Beaumont Products "All opinions and comments expressed are my own, have no relation to Beaumont Products, are fully copyrighted, and may not be used without written permission."
  • @Bobzchemist    Thanks for the tips.  Just to clarify I am using something like this and not a kitchen-aid stick blender.

    https://homogenizers.net/products/d500-homogenizer?nosto=productpage-nosto-1

    Is this still not enough sheer?  We have a huge colloid mill but not for lab batches.
  • Well, "enough" shear should be determined by results. How are your Hegman/FOG readings?

    That homogenizer should probably work for batches up to 100 grams or so. Anything larger will likely take hours to grind small enough.
    Robert Zonis, Sr. Formulation Chemist, Beaumont Products "All opinions and comments expressed are my own, have no relation to Beaumont Products, are fully copyrighted, and may not be used without written permission."
  • Robert Zonis, Sr. Formulation Chemist, Beaumont Products "All opinions and comments expressed are my own, have no relation to Beaumont Products, are fully copyrighted, and may not be used without written permission."
  • @Bobzchemist

    Actually had some success using your tips, thank you.  I just increased my sheer and mixing time with my lab homogenizer.  We don't have a hegman gauge so I can't get any number from our plant mill.  But since this is just a lab project I don't have to worry about that for now.  
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