Home Cosmetic Science Talk Formulating Dimethyl Isosorbide - Better than Propylene Glycol as a Benzoyl Peroxide solvent & penetration aid?

  • AuroraBorealis

    Member
    June 25, 2015 at 1:44 pm

    Because PG has a poor reputation among the masses as ‘anti-freeze’ hence the alternatives are often explored.

  • zink

    Member
    June 25, 2015 at 5:15 pm

    Or why not Butylene Glycol ;)

  • billichemist

    Member
    June 30, 2015 at 2:14 am

    isnt DMI better for dissolving Benzyl peroxide than PG?

  • victoriayepez

    Member
    November 6, 2017 at 3:37 pm

    Any word on whats better between DMI and PG? 

  • drbobverdient-biz

    Member
    November 6, 2017 at 4:50 pm

    1,3 Propanediol should at least be similar toPG!

  • zink

    Member
    November 6, 2017 at 5:58 pm

    I believe DMI is better for dissolving and possibly also stabilizing BP. That being said I haven’t done any empirical testing, but it wouldn’t be too expensive, BP HPLC analysis is only $120 with Custom Analytics. 

  • drbobverdient-biz

    Member
    November 6, 2017 at 7:14 pm

    DMI will give an odor:found Grant to be best.

  • markbroussard

    Member
    November 6, 2017 at 8:34 pm

    Yes, I have had not one client elect to use DMI (the Grant product) after they get a whiff of their product into which DMI has been incorporated.  So, I simply no longer consider it as an ingredient option.

  • zaidjeber

    Member
    November 7, 2017 at 2:53 am

    What about DMSO “dimethyl sulfoxide”, has it been used in cosmetic as solvent?
    I did use it experimentally in lab animals during my studies as solvent for some herb oil extracts and also in formulating topical pesticides for pets (as skin penetration aid)

  • belassi

    Member
    November 7, 2017 at 6:21 pm

    What about DMSO “dimethyl sulfoxide”, has it been used in cosmetic as solvent?
    Really? If you put it on your skin, reportedly, you will taste it pretty rapidly.

  • bill_toge

    Member
    November 7, 2017 at 6:55 pm

    @zaidjeber not in Europe; it’s been banned from cosmetics there since 1979

  • zink

    Member
    November 7, 2017 at 9:22 pm

    @zaidjeber nope, not ok to use in the US in cosmetics, which doesn’t stop some brand from selling DMSO cream “not for cosmetic use”

    The scent of DMI can be masked, really depends how much you’re using.

  • zaidjeber

    Member
    November 10, 2017 at 4:18 am

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